Wisconsin Alumni Research Foundation

Technology

HUMAN BLOOD-BRAIN BARRIER MODEL FOR IMMUNOLOGICAL STUDIES

A research collaboration between UW-Madison and the University of Bern has resulted in a new protocol for generating cells that can be used to better model the response and behavior of immune cells in...
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Eric Shusta, Hideaki Nishihara, Benjamin Gastfriend, Sean Palecek, Britta Engelhardt | P200363US03

Technology

Method Of Manufacturing Micelles For Drug Delivery

UW Madison researchers have developed a novel way to manufacture large amount of micellular paclitaxel. Rather than using organic solvents to get the paclitaxel solubilized and loaded into micelles, t...
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Glen Kwon, Morteza Rasoulianboroujeni, Rae Hyung Kang | P220070US02

Technology

UW-Madison researchers have developed a highly efficient biocatalytic route for production of diverse γ-hydroxy amino acids starting from L-aspartate and readily available aldehydes. The method ...
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Andrew Buller, Jonathan Ellis, Prasanth Kumar | P190336US02

Technology

MUTANT ACE2 PROTEINS AND METHODS OF USING SAME

UW-Madison researchers have identified novel ACE2 mutants having enhanced activity and/or specificity in hydrolyzing angiotensin II. ACE2 (angiotensin converting enzyme 2) is a key metalloprotease of ...
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Philip Romero, Peter Heinzelman | P210188WO01

Technology

VACO6

A UW-Madison researcher has established a cell line, called VACO6, from a discarded tissue specimen of a surgically resected primary human colon cancer. The detailed characteristics of the clinical do...
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James Willson | P230180US01

Technology

UW-Madison researchers have developed a titin DNA construct (a ‘titin minigene plasmid’) that is useful for identifying agents that modulate the titin size reduction that correlates with a...
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Wei Guo, Yanghai Zhang | P230097US01

Technology

Primatized Mouse

The present invention is a novel, primatized mouse model for studying the immune system of nonhuman primates in a relatively low-cost mouse. The UW-Madison inventor used a different source of immune c...
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Matthew Brown | P210237US02

Technology

Knockout of GFAP In the Mouse (Model tm1Mes)

UW-Madison researchers have developed a GFAP knockout mouse model, designated tm1Mes, that has been engineered to have an internal deletion of the Gfap gene that renders it completely non-functional. ...
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Albee Messing, Maureen McCall | P220164US01

Technology

Mouse Models for Protein Granule Diseases

Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as ver...
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Wei Guo | P210193US01

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