The ability to deliver biomolecules, such as proteins or nucleic acids, into cells has many therapeutic and research applications. Polyelectrolyte multilayers (PEMs) have been used to deliver biomolec...
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The ability to deliver proteins into cells has many therapeutic and research applications. However, peptide drugs and therapeutic proteins are notoriously difficult to administer, in part because of t...
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Embryonic stem cells are undifferentiated cells that can differentiate into a number of progenitor cell types. A trophoblast is a differentiated cell that is a precursor of the cells which participate...
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Although techniques exist for differentiating human embryonic stem cells (ES cells) into a number of specific cell types, no method currently exists for directing ES cell cultures to become endothelia...
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Influenza is a major disease in humans that can be prevented by vaccination. Because new epidemic strains arise every year or two, the conventional influenza vaccine must be adapted almost every year,...
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Mesenchymal stem cells (MSCs) are precursors to mesenchymal tissues, such as bone, dental tissue, cartilage, tendon, bone marrow stroma, hematopoietic lineages, and muscle. Bone marrow is a useful sou...
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Thin films and coatings that allow the sustained release of DNA from surfaces play an important role in the development of localized approaches to gene therapy. For example, polymer-coated intravascul...
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Development of most tissue types involves a complex interplay of multiple growth factors in well defined locations, leading to controlled differentiation of precursor cells into mature, tissue-specifi...
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Dendritic cells are used as a base for vaccines and in the study of antigen processing within the human body. However, obtaining large quantities of the cells, which are generated in bone marrow, is l...
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Type I diabetes, one of the most common autoimmune diseases in humans, is caused by destruction of pancreatic islet beta cells. Although its symptoms can be controlled, the disease is irreversible. ...
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Human embryonic stem (hES) cells have the potential to provide a source of specific cell types for research and ultimately, for therapeutic transplantation into humans.
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Under physiological conditions, bone tissue regeneration involves a complex interplay of multiple biologically active molecules and stem cells. The molecules are often presented sequentially in cascad...
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Dendritic cells play an important role in the process of initiating immune response. They are present in small quantities in tissues, such as skin and lung, that are in contact with the external envir...
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Oral ingestion of pharmaceuticals is considered the safest, most convenient and most economical method of drug administration.  However, many therapeutic drugs cannot be delivered orally because ...
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Human embryonic stem (ES) cells are potentially capable of supplying cells and tissues for replacement of defective human tissue. However, procedures currently used to culture human ES cells involve t...
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Even though therapeutic compounds have been developed for neurologic disorders, such as Alzheimer’s disease, these conditions remain difficult to treat, largely because of the blood-brain barrie...
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Many drugs that are potentially efficacious for treating diseases such as cancer have limited usefulness because they are relatively insoluble and/or toxic. Polymeric micelles can serve as vehicles fo...
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Many drugs that are potentially efficacious for treating diseases, such as cancer, have limited usefulness because they are relatively insoluble. Preparing these drugs in an amorphous, or “glass...
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