The antibiotic vancomycin targets the peptidoglycan-containing bacterial cell wall. Inducible resistance to vancomycin and other glycopeptide antibiotics is becoming a serious health problem, necessit...
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Effective and non-destructive treatments are needed for diabetic retinopathy, a major cause of blindness in the United States. Thrombospondin1 (TSP1), a matricellular protein that inhibits angiogenesi...
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In patients who develop breast cancer, malignant tumors frequently begin in somatic mammary stem cells. In addition, breast tumors have a stem cell component that propagates the tumor, which may expla...
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Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. Inhibitors of SCD may be useful therapeutics for diseases such as obesity and diabetes.
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Approximately one-third of the world’s population is infected with the bacterium Mycobacterium tuberculosis, the causative agent of tuberculosis (TB).  Five to 10 percent of non-immunocompr...
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Johne’s disease is a contagious, chronic and usually fatal wasting disease that primarily affects the small intestine of ruminants. It is a worldwide problem with no known treatment and infects ...
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Microorganisms produce a variety of biologically active secondary metabolites, which display a range of useful antibiotic and immunosuppressant activities. One class of secondary metabolites, known as...
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As the incidence of antibiotic resistance among bacteria continues to rise, the discovery of new antibacterial compounds has become increasingly critical to fighting infectious disease. According to t...
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